Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms
D Brennan, Y Hu, A Kljuic, YW Choi, S Joubeh… - Differentiation, 2004 - Elsevier
The four isoforms of desmosomal cadherin desmogleins (Dsg1–4) are expressed in
epithelial tissues in a differentiation-specific manner. Extensive sequencing of the human
genome has revealed only one copy of the Dsg1 gene. However, we recently cloned two
novel additional mouse Dsg1 genes, Dsg1-β and-γ, which flank the original Dsg1-α on
chromosome 18. Sequence conservation between the Dsg1 isoforms diverged significantly
at exon 11, particularly in the region that encodes for the extracellular anchoring (EA) …
epithelial tissues in a differentiation-specific manner. Extensive sequencing of the human
genome has revealed only one copy of the Dsg1 gene. However, we recently cloned two
novel additional mouse Dsg1 genes, Dsg1-β and-γ, which flank the original Dsg1-α on
chromosome 18. Sequence conservation between the Dsg1 isoforms diverged significantly
at exon 11, particularly in the region that encodes for the extracellular anchoring (EA) …
