The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis
Climacteric, 2019•Taylor & Francis
Objective: The aim of this study was to estimate the global prevalence of primary ovarian
insufficiency (POI) and early menopause (EM). Methods: A comprehensive literature search
was performed in several databases to retrieve relevant English articles published between
1980 and 2017. To assess the methodological quality of the studies, the Newcastle-Ottawa
Scale was used. The heterogeneity of results across the studies was assessed using
Cochran's Q test and quantified by the I 2 statistic. Prevalence estimates of all studies were …
insufficiency (POI) and early menopause (EM). Methods: A comprehensive literature search
was performed in several databases to retrieve relevant English articles published between
1980 and 2017. To assess the methodological quality of the studies, the Newcastle-Ottawa
Scale was used. The heterogeneity of results across the studies was assessed using
Cochran's Q test and quantified by the I 2 statistic. Prevalence estimates of all studies were …
Abstract
Objective: The aim of this study was to estimate the global prevalence of primary ovarian insufficiency (POI) and early menopause (EM).
Methods: A comprehensive literature search was performed in several databases to retrieve relevant English articles published between 1980 and 2017. To assess the methodological quality of the studies, the Newcastle-Ottawa Scale was used. The heterogeneity of results across the studies was assessed using Cochran’s Q test and quantified by the I2 statistic. Prevalence estimates of all studies were pooled using a random-effects meta-analysis model at a confidence level of 95%.
Results: A total of 8937 potentially relevant articles were identified from the initial searches. Thirty-one studies met the inclusion criteria and were included in this meta-analysis. The pooled prevalence of POI and EM was calculated as 3.7% (95% confidence interval: 3.1, 4.3) and 12.2% (95% confidence interval: 10.5, 14), respectively. The prevalence of POI was higher in medium and low Human Development Index countries. The prevalence trend did not change over time.
Conclusion: The prevalence of POI and EM in women is considerable. The results of this study could contribute to consciousness-raising of health policy-makers toward the necessity of prioritizing, planning, and allocating health resources as preventive and treatment interventions for these women.
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