[HTML][HTML] JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation
MY Youn, A Yokoyama, S Fujiyama-Nakamura… - Journal of Biological …, 2012 - ASBMB
Osteoclastogenesis is a highly regulated process governed by diverse classes of regulators.
Among them, nuclear factor of activated T-cells calcineurin-dependent 1 (NFATc1) is the
primary osteoclastogenic transcription factor, and its expression is transcriptionally induced
during early osteoclastogenesis by receptor activation of nuclear factor κB ligand (RANKL),
an osteoclastogenic cytokine. Here, we report the novel enzymatic function of JMJD5, which
regulates NFATc1 protein stability. Among the tested Jumonji C (JmjC) domain-containing …
Among them, nuclear factor of activated T-cells calcineurin-dependent 1 (NFATc1) is the
primary osteoclastogenic transcription factor, and its expression is transcriptionally induced
during early osteoclastogenesis by receptor activation of nuclear factor κB ligand (RANKL),
an osteoclastogenic cytokine. Here, we report the novel enzymatic function of JMJD5, which
regulates NFATc1 protein stability. Among the tested Jumonji C (JmjC) domain-containing …