Ceramide and the mitochondrial respiratory chain

A Kogot-Levin, A Saada - Biochimie, 2014 - Elsevier
Ceramide is a group of sphingolipids found in cell membranes, composed of a sphingoid
base linked to a fatty acid of varying chain length. Initially regarded as purely structural
components, this group of molecules is now recognized as a key signaling and regulatory
elements in cell biology. Ceramide species differing in acyl chain length, with distinct
biophysical properties, execute distinct functions and effects. Some of these modulate
mitochondrial function and oxidative phosphorylation (OXPHOS). Certain ceramides were …