Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
A Tokumura, E Majima, Y Kariya, K Tominaga… - Journal of Biological …, 2002 - ASBMB
We purified human plasma lysophospholipase D that produces physiologically active
lysophosphatidic acid and showed that it is a soluble form of autotaxin, an ecto-nucleotide
pyrophosphatase/phosphodiesterase, originally found as a tumor cell motility-stimulating
factor. Its lower K m value for a lysophosphatidylcholine than that for a synthetic substrate of
nucleotide suggests that lysophosphatidylcholine is a more likely physiological substrate for
autotaxin and that its predicted physiological and pathophysiological functions could be …
lysophosphatidic acid and showed that it is a soluble form of autotaxin, an ecto-nucleotide
pyrophosphatase/phosphodiesterase, originally found as a tumor cell motility-stimulating
factor. Its lower K m value for a lysophosphatidylcholine than that for a synthetic substrate of
nucleotide suggests that lysophosphatidylcholine is a more likely physiological substrate for
autotaxin and that its predicted physiological and pathophysiological functions could be …
