[HTML][HTML] Lymphotoxin-β receptor mediates NEMO-independent NF-κB activation
T Saitoh, H Nakano, N Yamamoto, S Yamaoka - FEBS letters, 2002 - Elsevier
T Saitoh, H Nakano, N Yamamoto, S Yamaoka
FEBS letters, 2002•ElsevierLymphotoxin-β receptor (LTβR) is a member of the tumor necrosis factor receptor (TNFR)
superfamily that activates nuclear factor-κB (NF-κB) through the IκB kinase (IKK) complex,
the core of which is comprised of IKK1, IKK2 and NF-κB essential modulator (NEMO). We
demonstrate here that the LTβR signaling to NF-κB activation does not necessarily require
NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB,
but not RelA subunits of NF-κB are found in the nuclear DNA binding complexes induced by …
superfamily that activates nuclear factor-κB (NF-κB) through the IκB kinase (IKK) complex,
the core of which is comprised of IKK1, IKK2 and NF-κB essential modulator (NEMO). We
demonstrate here that the LTβR signaling to NF-κB activation does not necessarily require
NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB,
but not RelA subunits of NF-κB are found in the nuclear DNA binding complexes induced by …
Lymphotoxin-β receptor (LTβR) is a member of the tumor necrosis factor receptor (TNFR) superfamily that activates nuclear factor-κB (NF-κB) through the IκB kinase (IKK) complex, the core of which is comprised of IKK1, IKK2 and NF-κB essential modulator (NEMO). We demonstrate here that the LTβR signaling to NF-κB activation does not necessarily require NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB, but not RelA subunits of NF-κB are found in the nuclear DNA binding complexes induced by the LTβR signaling. Our results thus disclose NEMO-independent NF-κB activation by LTβR.
Elsevier
