Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting
approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal
uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the
fetus. There is no treatment that can improve uteroplacental perfusion and thereby increase
fetal growth in the uterus. Maternal uterine artery gene therapy presents a promising
treatment strategy for IUGR, with the use of adenoviral vectors encoding for proteins such as …