Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response …
Y Fu, L Maianu, BR Melbert, WT Garvey - Blood cells, molecules, and …, 2004 - Elsevier
Cellular glucose uptake is mediated by a family of facilitative glucose transporters (GLUT)
exhibiting differences in kinetics, substrate specificity, and tissue-specific expression. GLUT
isoform expression has not been comprehensively studied in human leukocytes, which
participate in immune and inflammatory responses and are critical for host defense.
Therefore, we studied the regulated expression of GLUT 1–5 mRNA and protein in isolated
human lymphocytes and monocytes and in human THP-1 macrophages and foam cells …
exhibiting differences in kinetics, substrate specificity, and tissue-specific expression. GLUT
isoform expression has not been comprehensively studied in human leukocytes, which
participate in immune and inflammatory responses and are critical for host defense.
Therefore, we studied the regulated expression of GLUT 1–5 mRNA and protein in isolated
human lymphocytes and monocytes and in human THP-1 macrophages and foam cells …