[PDF][PDF] Biosynthesis of glucocorticoids in tumors
N Cirillo - Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Journal of Clinical Investigation, 2023•Am Soc Clin Investig
Figure 1. Main biosynthetic pathways of corticosteroids in mice. In mice, like in humans,
aldosterone biosynthesis is restricted to the zona glomerulosa. Unlike that in humans, the
major glucocorticoid synthesized in mice is corticosterone (instead of cortisol), which is
produced from the same precursor deoxycorticosterone by 11β-hydroxylase (CYP11B1) in
the zona fasciculata (zF). Therefore, in mice, corticosterone is both an intermediate (zona
glomerulosa [zG]) and end product (zF) of steroid biosynthesis.
aldosterone biosynthesis is restricted to the zona glomerulosa. Unlike that in humans, the
major glucocorticoid synthesized in mice is corticosterone (instead of cortisol), which is
produced from the same precursor deoxycorticosterone by 11β-hydroxylase (CYP11B1) in
the zona fasciculata (zF). Therefore, in mice, corticosterone is both an intermediate (zona
glomerulosa [zG]) and end product (zF) of steroid biosynthesis.
Figure 1. Main biosynthetic pathways of corticosteroids in mice. In mice, like in humans, aldosterone biosynthesis is restricted to the zona glomerulosa. Unlike that in humans, the major glucocorticoid synthesized in mice is corticosterone (instead of cortisol), which is produced from the same precursor deoxycorticosterone by 11β-hydroxylase (CYP11B1) in the zona fasciculata (zF). Therefore, in mice, corticosterone is both an intermediate (zona glomerulosa [zG]) and end product (zF) of steroid biosynthesis.
The Journal of Clinical Investigation