COX-2 regulates the proliferation of glioma stem like cells
Cancer stem-like cells (CSCs) possessing features of neural precursor cells (NPC) influence
initiation, recurrence and chemoresistance of glioblastoma multiforme (GBM). As
inflammation is crucial for glioblastoma progression we investigated the effect of chronic IL-
1β treatment on CSCs derived from glioblastoma cell line U87MG. Exposure to IL-1β for
10days increased (i) accumulation of 8-OHdG–a key biomarker of oxidative DNA
damage;(ii) DNA damage response (DDR) indicators γH2AX, ATM and DNA-PK;(iii) nuclear …
initiation, recurrence and chemoresistance of glioblastoma multiforme (GBM). As
inflammation is crucial for glioblastoma progression we investigated the effect of chronic IL-
1β treatment on CSCs derived from glioblastoma cell line U87MG. Exposure to IL-1β for
10days increased (i) accumulation of 8-OHdG–a key biomarker of oxidative DNA
damage;(ii) DNA damage response (DDR) indicators γH2AX, ATM and DNA-PK;(iii) nuclear …