Effect of hormone replacement therapy on lipoprotein (a) and lipid levels in postmenopausal women: influence of various progestogens and duration of therapy

CJ Kim, YK Min, WS Ryu, JW Kwak… - Archives of Internal …, 1996 - jamanetwork.com
Background: Estrogen replacement therapy in post-menopausal women reduces the risk of
coronary artery disease. One of the possible mechanisms of this effect is the modification of
lipid profiles. However, there is controversy concerning the effects on lipoprotein (a)[Lp (a)]
and lipid levels of progestogens administered with estrogen. Methods: Five hundred fifty-one
postmenopausal women were divided into 5 groups: group 1, 0.625 mg of conjugated
equine estrogen (CEE)(n= 140); group 2, 0.625 mg of CEE plus 5 mg of …