Prostatic cancer treated by orchiectomy: the five year results

C Huggins - Journal of the American Medical Association, 1946 - jamanetwork.com
Five years is a customary period to appraise the results of treatments of cancer, and this time
has elapsed since the introduction of the endocrine therapy of prostatic carcinoma. The
antiandrogenic treatment consisting of orchiectomy or the administration of estrogen has
proved to have both theoretical and practical significance. There has emerged from this
study the fact that cancer of the prostate is usually not autonomous, since the neoplasm
grows or shrinks when androgens are administered or eliminated. The antiandrogenic …