Effect of early postnatal exposure to valproate on neurobehavioral development and regional BDNF expression in two strains of mice
KG Bath, T Pimentel - Epilepsy & Behavior, 2017 - Elsevier
Valproate has been used for over 30 years as a first-line treatment for epilepsy. In recent
years, prenatal exposure to valproate has been associated with teratogenic effects, limiting
its use in women that are pregnant or of childbearing age. However, despite its potential
detrimental effects on development, valproate continues to be prescribed at high rates in
pediatric populations in some countries. Animal models allow us to test hypotheses
regarding the potential effects of postnatal valproate exposure on neurobehavioral …
years, prenatal exposure to valproate has been associated with teratogenic effects, limiting
its use in women that are pregnant or of childbearing age. However, despite its potential
detrimental effects on development, valproate continues to be prescribed at high rates in
pediatric populations in some countries. Animal models allow us to test hypotheses
regarding the potential effects of postnatal valproate exposure on neurobehavioral …
